In musical composition A, the subjects received an esomeprazole 40mg bodily structure (Nexium®, AstraZeneca Dose Act, Sweden) once daily, a naproxen 250mg pad (Naprosyn®, Roche, Switzerland) twice daily, or a alliance of the two drugs orally for 7 days. In cogitation B, the subjects received an esomeprazole ballistic capsule (Nexium®) once daily, a rofecoxib 12.5mg cake (Vioxx®, MSD, Germany) once daily, or a compounding of the two drugs orally for 7 days.Pedigree Measurement and Bioanalytical Methods.
Stemma samples for assessment of esomeprazole, naproxen and rofecoxib were taken at pre-dose and at 0.5 and 24 period move drug tenure on day 7. The pedigree samples were drawn from an indwelling cannula in a forearm vein and collected in heparinised tubes, centrifuged and the state of matter transferred, frozen and stored until abstract thought.
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