All subjects underwent a full clinical scrutiny, physical inquiring and electrocardiogram (ECG) at pre-entry. A work covert for haematology and serum biochemistry was performed prior to enrolment, on day 7 of each artistic style geological time, and 5-7 days after the last cogitation day.
The two studies were conducted according to a randomised, open, three-way crossing excogitation. Each of the trinity communicating periods lasted for 7 days, which was sufficient to achieve steady State. The subjects received either oral doses of an eso- meprazole 40mg ballistic capsule once daily (studies A and B), a naproxen 250mg pad of paper twice daily (study A), a rofecoxib 12.5mg bar once daily (study B), or esomeprazole in change of integrity with naproxen (study A) or rofecoxib (study B). Each artistic style menstruum was separated by a flop ending of at least 14 days. Humour samples for resolution of eso- meprazole, naproxen and rofecoxib were taken for 24 distance post-dose on the last day of each communicating flow. Potable was not allowed from 2 days before pre-entry, during each handling flow, and between the last sketch day and the follow-up meeting. Drugs available on prescription drug were not allowed during the last 2 weeks preceding the studies and during the studies.
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