Pharmacokinetic and Statistical Analyses.

The state diligence of esomeprazole was analysed using normal period of time fluid chromatography with ultraviolet uncovering. The limit point of measurement (LOQ) for this acting is 25 nmol/L with a coefficient of change (CV) of <20%. The calcedony property of naproxen was determined using liquidity chromatography and fluorescence espial. The flow rate was 0.5 mL/min and the medical aid amount was 20-40µL. The possession time was 3.0 minutes and absolute human action in the assiduousness piece of ground of 0.5-500 µmol/L was between 89% and 100%. The LOQ was 0.5 µmol/L (CV =20%). Intra- and interassay repeatability were 4-5% and 4-6%, respectively. Rofecoxib plasm attention was also determined using consonant chromatography and fluorescence police work. The flow rate was 1.2 mL/min and the insertion magnitude was 150µL. The holding time was 4.5 minutes and the absolute betterment in the density miscellany of 3.0-200 nmol/L was between 90% and 91%. The LOQ was 1.5 nmol/L (CV =20%). Both intra- and interassay repeatability were 6-7%. The calcedony samples were analysed for esomeprazole, naproxen and rofecoxib at Quintiles AB, Uppsala, Sweden.